Genetic Factors in Determining Bone Mass
نویسندگان
چکیده
منابع مشابه
Genetic Factors in Bone Disorders
Genetic factors and their resulting phenotypes were evaluated in three different bone disorders: osteogenesis imperfecta (OI), juvenile idiopathic osteoporosis (JIO), and stress fractures. The spectrum of the OI phenotypes caused by mutations in the COL1A1 and COL1A2 genes is well defined, but the mechanisms by which the variations affect the hearing phenotype are not wellknown. A total of 54 F...
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Currently available non-invasive clinical methods for diagnosing osteoporosis are mainly associated with ionizing radiation. Ultrasonic assessment of bone disease is a more recent technology. A theoretical explanation for the relationship between ultrasonic parameters and bone structure is necessary. Thus, two types of bone samples of perspex (HAP) and perspex-glass beads were produced. Ea...
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Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density (BMD) and other determinants of fracture risk-such as ultrasound properties of bone, skeletal geometry, and bone turnover-is high, although heritability of fracture is modes...
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UNLABELLED Several studies have shown that low body mass index (BMI) is associated with low BMD and fractures. However, the results that have been published from studies on reproductive factors and BMD are extremely controversial, with some demonstrating a beneficial effect, while others show a detrimental impact of these factors on bone mass. OBJECTIVE To study the influence of several gynec...
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OBJECTIVE To evaluate the contributions of adolescent calcium intake, oral contraceptive use, and exercise on bone mass and bone strength.Study design Eighty white women participated in 10 years of the Penn State Young Women's Health Study, a longitudinal study of community participants. We measured bone mineral mass (g), density (BMD, g/cm(2)), and body composition from dual energy x-ray absor...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1973
ISSN: 0021-9738
DOI: 10.1172/jci107476